Intermittent dietary methionine deprivation facilitates tumoral ferroptosis and synergizes with checkpoint blockade

Abstract Dietary methionine interventions are beneficial to apoptosis-inducing chemotherapy and radiotherapy for cancer, while their effects on ferroptosis-targeting therapy and immunotherapy are unknown.Here we show the length of time methionine deprivation affects tumoral ferroptosis differently.Prolonged methionine deprivation prevents glutathio

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Temperature-responsive self-contraction nanofiber/hydrogel composite dressing facilitates the healing of diabetic-infected wounds

Bacterial infections and long-term inflammation cause serious secondary damage to chronic diabetic wounds and hinder the wound healing processes.Currently, multifunctional hydrogels have shown promising effects in chronic wound repair.However, traditional hydrogels only keep the wound moist and protect it from bacterial infection, and cannot provid

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